| First Author | Timofeeva OA | Year | 1999 |
| Journal | Genetika | Volume | 35 |
| Issue | 9 | Pages | 1309-12 |
| PubMed ID | 10576066 | Mgi Jnum | J:57706 |
| Mgi Id | MGI:1345566 | Citation | Timofeeva OA, et al. (1999) [The study of correlation between the K-ras genotype and murine susceptibility to chemically induced lung neoplasms]. Genetika 35(9):1309-12 |
| abstractText | The susceptibility of the ICR, DD/He and CC57/BR mice to urethane-induced lung tumors was analyzed in comparison with the A/He (highly susceptible) and AKR (resistant) lines of mice. Allelic variants of the K-Ras gene intron 2 in these lines have been determined. Susceptibility of the ICR mice was similar to that of the A mice, and intron 2 of the K-Ras ICR gene carried the 37-bp deletion analogous to that described in the A/He line. The DD mice intron 2 also contained the deletion, but despite the presence of the 'susceptible' K-Ras allele, the DD/He mice were resistant to urethane induction of lung tumors. The CC57BR line carried the deletion and demonstrated relatively high susceptibility. Our findings indicate that the K-Ras gene may be important in the chemical induction of lung tumors. |
