Type | MGI:General | Description | after intranasal administration of house dust mites (HDMs) to induce allergic airway inflammation, mice exhibit a lower infiltration of eosinophils in their lungs relative to heterozygous controls, as determined by eosinophil cell % of lung CD45+ immune cells immunostaining of Siglec-F (which labels the populations of eosinophils and alveolar macrophages), confirmed reduced eosinophil abundance in the lung tissues after HDM treatment |