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Protein Coding Gene : Rpa1 replication protein A1
Primary Identifier  MGI:1915525 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  68275
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables chromatin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; homeostasis of number of cells within a tissue; and in utero embryonic development. Located in lateral element and male germ cell nucleus. Is expressed in respiratory system; submandibular gland; testis; and ventricular layer. Orthologous to human RPA1 (replication protein A1).
PHENOTYPE: Homozygous null mice display embryonic lethality before implantation and impaired cell proliferation. Heterozygous null mice display decreased survival, chromosomal instability, impaired double strand break repair, and develop lymphomas. [provided by MGI curators]
  • synonyms:
  • AA589576,
  • expressed sequence AA589576,
  • MGI:1194911,
  • RIKEN cDNA 5031405K23 gene,
  • MGI:2144576,
  • replication protein A,
  • RF-A,
  • AW557552,
  • Rpa,
  • MGI:2144032,
  • 70kDa,
  • 5031405K23Rik,
  • replication protein A1,
  • Rpa1,
  • RP-A,
  • expressed sequence AW557552
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

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2 Involved In Mutations

Trail: ProteinCodingGene

0 Strain

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

69 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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