| First Author | Shen WH | Year | 1994 |
| Journal | Cell | Volume | 77 |
| Issue | 5 | Pages | 651-61 |
| PubMed ID | 8205615 | Mgi Jnum | J:18562 |
| Mgi Id | MGI:66831 | Doi | 10.1016/0092-8674(94)90050-7 |
| Citation | Shen WH, et al. (1994) Nuclear receptor steroidogenic factor 1 regulates the mullerian inhibiting substance gene: a link to the sex determination cascade. Cell 77(5):651-61 |
| abstractText | Normal male sex differentiation requires that Sertoli cells in the embryonic testes produce mullerian inhibiting substance (MIS), a TGF beta-like hormone that causes mullerian duct regression. In primary Sertoli cells, the orphan nuclear receptor, steroidogenic factor 1 (SF-1), regulates the MIS gene by binding to a conserved upstream regulatory element. In heterologous (HeLa) cells, MIS gene activation by SF-1 requires removal of the SF-1 ligand-binding domain, implicating a Sertoli cell-specific ligand or cofactor. Finally, the sexually dimorphic expression of SF-1 during development coincides with MIS expression and mullerian duct regression. We propose that SF-1 regulates MIS in vivo and participates directly in the process of mammalian sex determination. |
