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Protein Coding Gene : Lrrk2 leucine-rich repeat kinase 2

Primary Identifier  MGI:1913975 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  66725
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables several functions, including beta-catenin destruction complex binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of catabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including Golgi organization; negative regulation of Notch signaling pathway; and protein import into nucleus. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum exit site; and mitochondrion. Part of Wnt signalosome and ribonucleoprotein complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb bud; and spinal cord. Used to study Parkinson's disease 8. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2).
PHENOTYPE: Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy. [provided by MGI curators]
  • synonyms:
  • cDNA sequence, clone 3-75,
  • D630001M17Rik,
  • 4921513O20Rik,
  • MGI:2685773,
  • RIKEN cDNA 9330188B09 gene,
  • 9330188B09Rik,
  • RIKEN cDNA D630001M17 gene,
  • MGI:1930800,
  • MGI:2442391,
  • LOC381026,
  • Gm927,
  • Lrrk2,
  • RIKEN cDNA 4921513O20 gene,
  • cI-46,
  • AW561911,
  • leucine-rich repeat kinase 2,
  • gene model 927, (NCBI)

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Genome

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0 Canonical

0 CDSs

0 Exons

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4 Involved In Mutations

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0 Transcripts

2 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

0 Targeted By

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Expression

Gene --> Expression annotations

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Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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0 Driver For