Primary Identifier | MGI:2445085 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 217935 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Predicted to enable dynein light chain binding activity. Predicted to be involved in cilium assembly; embryonic skeletal system morphogenesis; and intraciliary retrograde transport. Predicted to act upstream of or within cell projection organization. Located in cilium. Is expressed in mandible; maxilla; olfactory epithelium; and orbito-sphenoid. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 8 with or without polydactyly. Orthologous to human DYNC2I1 (dynein 2 intermediate chain 1). PHENOTYPE: Mice homozygous for a null allele display embryonic lethality during organogenesis with abnormal head development. [provided by MGI curators] |