| Type | MGI:General | Description | homozygotes exhibit highly reduced Cytidine (C) to Uridine (U) editing of Apob RNA relative to wild-type controls Western blot of protein extracts from the small intestine of adult homozygotes revealed that APOB100 (encoded by unedited mRNA) is the predominant APOB isoform, unlike in wild-type controls where APOB48 (encoded by edited Apob) is the main detectable isoform RT-PCR analysis confirmed a significant reduction in C to U editing of Apob RNA and other RNA molecules that are potential targets of this post-transcriptional modification in the small intestine, while their level of gene expression was not changed |
