| First Author | Eichholtz-Wirth H | Year | 2003 |
| Journal | Cancer Lett | Volume | 194 |
| Issue | 1 | Pages | 81-9 |
| PubMed ID | 12706861 | Mgi Jnum | J:94505 |
| Mgi Id | MGI:3513198 | Doi | 10.1016/s0304-3835(03)00009-0 |
| Citation | Eichholtz-Wirth H, et al. (2003) Overexpression of the 'silencer of death domain', SODD/BAG-4, modulates both TNFR1- and CD95-dependent cell death pathways. Cancer Lett 194(1):81-9 |
| abstractText | The involvement of SODD/BAG-4 was studied in TNFR1 signaling, using SODD/BAG-4- overexpressing HeLa cells as a cellular model. Stable transfection of a SODD/BAG-4 cDNA leads to increased levels of the full-length 70-kDa protein and additional C-terminal fragments as well as altered expression of BAG-1. Concomitantly, the protein amounts of both the TNFR1 and, unexpectedly, the CD95 receptors are elevated. These biochemical changes are paralleled and confirmed by a reduced cellular sensitivity to treatment with extracellular TNFalpha and CD95 ligand. Moreover, ATP depletion by oligomycin is less toxic in SODD/BAG-4 overexpressing clones. The radiosensitivity is reduced in some, but not in all of these clones. Our results indicate that SODD/BAG-4 is not only a silencer of TNFR1 but also a modulator of CD95 activity, regulating the balance of both death-promoting and -depressing signals. |
