| First Author | Yoo J | Year | 1996 |
| Journal | DNA Cell Biol | Volume | 15 |
| Issue | 5 | Pages | 377-85 |
| PubMed ID | 8924212 | Mgi Jnum | J:33113 |
| Mgi Id | MGI:80594 | Doi | 10.1089/dna.1996.15.377 |
| Citation | Yoo J, et al. (1996) Genomic organization and chromosomal mapping of the bovine Fas/APO-1 gene. DNA Cell Biol 15(5):377-85 |
| abstractText | The cell-surface protein Fas (APO-1) is a member of the tumor necrosis factor receptor (TNFR) superfamily and transduces apoptosis following binding of Fas ligand or exposure to certain anti-Fas antibodies. We have isolated the bovine Fas (bFas) gene and determined its genomic organization and chromosomal location. Our data indicate that bFas is a single-copy gene that contains 9 exons and spans approximately 31.5 kb. The 5'-flanking region lacks conventional TATA and CCAAT elements, but contains several putative regulatory elements, including multiple copies of Sp1, AP-2, E-box, and N-box consensus sites. Linkage analysis of two (CA) dinucleotide repeat microsatellites within intron 1 and physical assignment by fluorescence in situ hybridization (FISH) placed the bFas gene on bovine chromosome 26. Collectively, these data provide a basis for understanding the regulatory mechanisms that control bFas gene expression. |
