| First Author | Heine M | Year | 2018 |
| Journal | Cell Metab | Volume | 28 |
| Issue | 4 | Pages | 644-655.e4 |
| PubMed ID | 30033199 | Mgi Jnum | J:269432 |
| Mgi Id | MGI:6270128 | Doi | 10.1016/j.cmet.2018.06.020 |
| Citation | Heine M, et al. (2018) Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice. Cell Metab 28(4):644-655.e4 |
| abstractText | The coordination of the organ-specific responses regulating systemic energy distribution to replenish lipid stores in acutely activated brown adipose tissue (BAT) remains elusive. Here, we show that short-term cold exposure or acute beta3-adrenergic receptor (beta3AR) stimulation results in secretion of the anabolic hormone insulin. This process is diminished in adipocyte-specific Atgl(-/-) mice, indicating that lipolysis in white adipose tissue (WAT) promotes insulin secretion. Inhibition of pancreatic beta cells abolished uptake of lipids delivered by triglyceride-rich lipoproteins into activated BAT. Both increased lipid uptake into BAT and whole-body energy expenditure in response to beta3AR stimulation were blunted in mice treated with the insulin receptor antagonist S961 or lacking the insulin receptor in brown adipocytes. In conclusion, we introduce the concept that acute cold and beta3AR stimulation trigger a systemic response involving WAT, beta cells, and BAT, which is essential for insulin-dependent fuel uptake and adaptive thermogenesis. |
