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Protein Coding Gene : Hectd3 HECT domain E3 ubiquitin protein ligase 3
Primary Identifier  MGI:1923858 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  76608
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables syntaxin binding activity and ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in perinuclear region of cytoplasm. Orthologous to human HECTD3 (HECT domain E3 ubiquitin protein ligase 3).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased susceptibility to intranasal bacterial infection due to suppressed bacterial intracellular replication. [provided by MGI curators]
  • synonyms:
  • HECT domain E3 ubiquitin protein ligase 3,
  • expressed sequence AW743312,
  • expressed sequence AI467540,
  • MGI:2140305,
  • MGI:2140618,
  • Hectd3,
  • AW743312,
  • AI467540,
  • RIKEN cDNA 1700064K09 gene,
  • 1700064K09Rik
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Features --> Cross References

Genome

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4 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

4 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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