| First Author | Xia D | Year | 2012 |
| Journal | Nat Med | Volume | 18 |
| Issue | 2 | Pages | 224-6 |
| PubMed ID | 22270723 | Mgi Jnum | J:181279 |
| Mgi Id | MGI:5310689 | Doi | 10.1038/nm.2608 |
| Citation | Xia D, et al. (2012) Prostaglandin E2 promotes intestinal tumor growth via DNA methylation. Nat Med 18(2):224-6 |
| abstractText | Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E(2) (PGE(2)) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE(2) in the promotion of tumor progression. |
