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Protein Coding Gene : P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1
Primary Identifier  MGI:1098235 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  18436
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables monoatomic cation channel activity and purinergic nucleotide receptor activity. Acts upstream of or within several processes, including platelet activation; regulation of monoatomic ion transport; and serotonin secretion by platelet. Located in external side of plasma membrane and postsynaptic membrane. Is expressed in several structures, including bladder; foregut-midgut junction; heart; liver lobe; and midgut. Orthologous to human P2RX1 (purinergic receptor P2X 1).
PHENOTYPE: Homozygotes for a targeted null mutation exhibit low male fertility due to impaired vas deferens contraction and reduced numbers of ejaculated sperm. Mutants also show mild hypertension and reduced susceptibility to experimental thromboembolism. [provided by MGI curators]
  • synonyms:
  • P2rx1,
  • RP-2,
  • MGI:2144602,
  • MGI:2144121,
  • BB122383,
  • MGI:105106,
  • expressed sequence BB122383,
  • P2x,
  • purinergic receptor P2X, ligand-gated ion channel, 1,
  • Pdcd3,
  • expressed sequence AI323649,
  • programmed cell death 3,
  • MGD-MRK-32146,
  • P2X1 receptor,
  • AI323649
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2 Involved In Mutations

Trail: ProteinCodingGene

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0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

7 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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