| First Author | Woyciechowski S | Year | 2020 |
| Journal | Eur J Immunol | Volume | 50 |
| Issue | 12 | Pages | 1952-1958 |
| PubMed ID | 32734619 | Mgi Jnum | J:299230 |
| Mgi Id | MGI:6479773 | Doi | 10.1002/eji.202048741 |
| Citation | Woyciechowski S, et al. (2020) NK1.1(+) innate lymphoid cells in salivary glands inhibit establishment of tissue-resident memory CD8(+) T cells in mice. Eur J Immunol 50(12):1952-1958 |
| abstractText | NK1.1(+) cells found in salivary glands (SG) represent a unique cell population of innate lymphoid cells (ILC) with characteristics of both conventional NK cells and ILC1. Here, we demonstrate that these NK1.1(+) cells limit the accumulation and differentiation of virus-specific tissue-resident memory CD8(+) T cells (TRM cells) in SG of mice infected with lymphocytic choriomeningitis virus (LCMV). The negative regulation of LCMV-specific CD8(+) TRM cells by NK1.1(+) cells in SG is independent of NKG2D, NKp46, TRAIL, and perforin. Moreover, analysis of NKp46(iCre+) Eomes(fl/fl) mice revealed that Eomes-dependent conventional NK cells are dispensable for negative regulation. Since the SG are prone to autoimmune reactions, regulation of TRM cells by tissue-resident ILC may be particularly important to prevent immunopathology in this organ. |
