| First Author | Inoue S | Year | 2012 |
| Journal | Proc Natl Acad Sci U S A | Volume | 109 |
| Issue | 30 | Pages | 12129-34 |
| PubMed ID | 22778420 | Mgi Jnum | J:186477 |
| Mgi Id | MGI:5432422 | Doi | 10.1073/pnas.1204480109 |
| Citation | Inoue S, et al. (2012) Enhancement of dendritic cell activation via CD40 ligand-expressing gammadelta T cells is responsible for protective immunity to Plasmodium parasites. Proc Natl Acad Sci U S A 109(30):12129-34 |
| abstractText | Previous reports have shown that gammadelta T cells are important for the elimination of malaria parasites in humans and mice. However, how gammadelta T cells are involved in protective immunity against blood-stage malaria remains unknown. We infected gammadelta T-cell-deficient (TCRdelta-KO) mice and control wild-type mice with Plasmodium berghei XAT, which is a nonlethal strain. Although infected red blood cells were eliminated within 30 d after infection, TCRdelta-KO mice could not clear the infected red blood cells, showed high parasitemia, and eventually died. Therefore, gammadelta T cells are essential for clearance of the parasites. Here, we found that gammadelta T cells play a key role in dendritic cell activation after Plasmodium infection. On day 5 postinfection, gammadelta T cells produced IFN-gamma and expressed CD40 ligand during dendritic cell activation. These results suggest that gammadelta T cells enhance dendritic cell activation via IFN-gamma and CD40 ligand-CD40 signaling. This hypothesis is supported strongly by the fact that in vivo induction of CD40 signaling prevented the death of TCRdelta-KO mice after infection with P. berghei XAT. This study improves our understanding of protective immunity against malaria and provides insights into gammadelta T-cell-mediated protective immunity against various infectious diseases. |
