| First Author | Liang D | Year | 2017 |
| Journal | J Immunol | Volume | 198 |
| Issue | 4 | Pages | 1429-1438 |
| PubMed ID | 28069804 | Mgi Jnum | J:361204 |
| Mgi Id | MGI:5926219 | Doi | 10.4049/jimmunol.1601510 |
| Citation | Liang D, et al. (2017) Functional Conversion and Dominance of gammadelta T Subset in Mouse Experimental Autoimmune Uveitis. J Immunol 198(4):1429-1438 |
| abstractText | We have previously shown that activated gammadelta T cells have a much stronger proinflammatory effect in the development of experimental autoimmune uveitis than their nonactivated counterparts. Our present study explored gammadelta T cell subsets are functionally distinct in autoimmune pathogenesis and determined the pathogenic contribution of biased Vgamma4+ gammadelta T cell activation in this disease. By systematically comparing two major peripheral gammadelta T cell subsets, the Vgamma1+ and the Vgamma4+ cells, we found that the Vgamma4+ cells were readily activated in B6 mice during experimental autoimmune uveitis development, whereas Vgamma1+ cells remained nonactivated. Cytokines that were abundantly found in the serum of immunized mice activated Vgamma4+, but did not activate Vgamma1+, cells. The Vgamma4+ cells had a strong proinflammatory activity, whereas the Vgamma1+ cells remained nonactivated when tested immediately after isolation from immunized mice. However, when the Vgamma1+ cells were activated in vitro, they promoted inflammation. Our results demonstrated that activation is a major factor in switching the enhancing and inhibiting effects of both Vgamma1+ and Vgamma4+ gammadelta T cell subsets, and that gammadelta T cell subsets differ greatly in their activation requirements. Whether the enhancing or inhibiting function of gammadelta T cells is dominant is mainly determined by the proportion of the gammadelta T cells that are activated versus the proportion not activated. |
