| First Author | Liang D | Year | 2013 |
| Journal | Invest Ophthalmol Vis Sci | Volume | 54 |
| Issue | 5 | Pages | 3493-503 |
| PubMed ID | 23611991 | Mgi Jnum | J:215289 |
| Mgi Id | MGI:5604996 | Doi | 10.1167/iovs.12-11432 |
| Citation | Liang D, et al. (2013) Retinoic acid inhibits CD25+ dendritic cell expansion and gammadelta T-cell activation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci 54(5):3493-503 |
| abstractText | PURPOSE: We determined the mechanism by which all-trans retinoic acid (ATRA) inhibits experimental autoimmune uveitis (EAU) and determined the role of gammadelta T cells in this autoimmune disease. METHODS: C57BL/6 (B6) mice were immunized with the uveitogenic, interphotoreceptor retinoid-binding protein1-20 peptide (IRBP1-20) in complete Freund's adjuvant (CFA), with or without a preceding ATRA treatment. Responses and pathogenic activity of Th1- and Th17-autoreactive T cells were compared, and the effects of ATRA on gammadelta T cells and CD25(+) dendritic cell (DC) subset were determined. Interactions among uveitogenic T cells, DC subsets, and gammadelta T cells were investigated. RESULTS: Administration of ATRA to B6 mice in which EAU was induced suppressed the response of Th17 autoreactive T cells, which was associated with decreased generation of the CD25(+) DC subset and suppressed activation of gammadelta T cells. Adoptively transferred gammadelta T cells isolated from ATRA-treated mice showed a diminished ability to promote the activation of Th17 autoreactive T cells in vitro and in vivo compared to gammadelta T cells from untreated donors. CONCLUSIONS: ATRA inhibits the expansion of CD25(+) DCs and gammadelta T-cell activation, thereby restraining the Th17 autoreactive T-cell response. |
