| First Author | Calabro S | Year | 2016 |
| Journal | Cell Rep | Volume | 16 |
| Issue | 9 | Pages | 2472-85 |
| PubMed ID | 27545885 | Mgi Jnum | J:238929 |
| Mgi Id | MGI:5824597 | Doi | 10.1016/j.celrep.2016.07.076 |
| Citation | Calabro S, et al. (2016) Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity. Cell Rep 16(9):2472-85 |
| abstractText | Evidence suggests that distinct splenic dendritic cell (DC) subsets activate either CD4+ or CD8+ T cells in vivo. This bias has been partially ascribed to differential antigen presentation; however, all DC subsets can activate both T cell lineages in vitro. Therefore, we tested whether the organization of DC and T cell subsets in the spleen dictated this preference. We discovered that CD4+ and CD8+ T cells segregated within splenic T cell zones prior to immunization. After intravenous immunization, the two major conventional DC populations, distinguished by 33D1 and XCR1 staining, migrated into separate regions of the T cell zone: 33D1+ DCs migrated into the CD4+ T cell area, whereas XCR1+ DCs migrated into the CD8+ T cell area. Thus, the post-immunization location of each DC subset correlated with the T cell lineage it preferentially primes. Preventing this co-localization selectively impaired either CD4+ or CD8+ T cell immunity to blood-borne antigens. |
