Primary Identifier | MGI:1098235 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 18436 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables monoatomic cation channel activity and purinergic nucleotide receptor activity. Acts upstream of or within several processes, including platelet activation; regulation of monoatomic ion transport; and serotonin secretion by platelet. Located in external side of plasma membrane and postsynaptic membrane. Is expressed in several structures, including bladder; foregut-midgut junction; heart; liver lobe; and midgut. Orthologous to human P2RX1 (purinergic receptor P2X 1). PHENOTYPE: Homozygotes for a targeted null mutation exhibit low male fertility due to impaired vas deferens contraction and reduced numbers of ejaculated sperm. Mutants also show mild hypertension and reduced susceptibility to experimental thromboembolism. [provided by MGI curators] |