| First Author | Ra H | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 9 | Pages | 1516-20 |
| PubMed ID | 19364507 | Mgi Jnum | J:148022 |
| Mgi Id | MGI:3843388 | Doi | 10.1016/j.febslet.2009.04.008 |
| Citation | Ra H, et al. (2009) Essential role of p53 in TPEN-induced neuronal apoptosis. FEBS Lett 583(9):1516-20 |
| abstractText | Depletion of intracellular zinc with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) induces protein synthesis-dependent apoptosis. In this study, we examined the requirement for p53 as an upstream transcription factor in TPEN-induced neuronal apoptosis. Chemical or genetic blockade of p53 markedly attenuated TPEN-induced neuronal apoptosis, while the stability and activity of p53 were increased by TPEN. In addition, expression of proapoptotic genes, PUMA and NOXA, and activation of caspase-11 were increased by TPEN in a p53-dependent manner. Inhibition of p53 blocked cytochrome C release from mitochondria to cytosol and prevented caspase-3 activation. Therefore, p53 may be an essential regulatory factor for TPEN-induced neuronal apoptosis. |
