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Publication : The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos.

First Author  Cao S Year  2003
Journal  Mol Cell Biol Volume  23
Issue  15 Pages  5301-7
PubMed ID  12861016 Mgi Jnum  J:84557
Mgi Id  MGI:2668284 Doi  10.1128/MCB.23.15.5301-5307.2003
Citation  Cao S, et al. (2003) The high-mobility-group box protein SSRP1/T160 is essential for cell viability in day 3.5 mouse embryos. Mol Cell Biol 23(15):5301-7
abstractText  The high-mobility-group (HMG) SSRP1 protein is a member of a conserved chromatin-remodeling complex (FACT/DUF/CP) implicated in DNA replication, basal and regulated transcription, and DNA repair. To assist in the functional analysis of SSRP1, the Ssrp1 gene was targeted in murine embryonic stem cells, and the mutation was introduced into the germ line. Embryos homozygous for the targeted allele die soon after implantation, and preimplantation blastocysts are defective for cell outgrowth and/or survival in vitro. The Ssrp1 mutation was also crossed into a p53 null background without affecting growth and/or survival defects caused by loss of Ssrp1 function. Thus, Ssrp1 appears to encode nonredundant and p53-independent functions that are essential for cell viability.
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