| First Author | Feng C | Year | 2021 |
| Journal | Immunology | Volume | 164 |
| Issue | 3 | Pages | 617-636 |
| PubMed ID | 34351636 | Mgi Jnum | J:344064 |
| Mgi Id | MGI:7294468 | Doi | 10.1111/imm.13398 |
| Citation | Feng C, et al. (2021) Critical roles of the E3 ubiquitin ligase FBW7 in B-cell response and the pathogenesis of experimental autoimmune arthritis. Immunology 164(3):617-636 |
| abstractText | Proper regulation of B-cell function is essential for effective humoral immunity and maintenance of immune tolerance. Here, we found that FBW7 (F-box/WD40 repeat-containing protein 7) is highly expressed in germinal centre B and B1 cells, and confirmed that it has an intrinsic role in maintaining homeostasis of mature B cells and B-1 cells. FBW7 deletion led to an impairment of antibody response, and although germinal centre formation was not affected, antibody class-switch recombination and affinity maturation processes were defective. Likewise, memory immune response was severely impaired. Moreover, FBW7 ablation ameliorated the pathogenesis of an autoimmune disease model, collagen-induced arthritis, by reducing the production of anti-collagen II autoantibodies. Taken together, these data suggest that FBW7 may be an attractive target for developing new therapeutics for the treatment of autoimmune diseases. |
