| First Author | Pregizer S | Year | 2018 |
| Journal | Orthopedic Research Society Annual Meeting | Pages | Abstract 0007 |
| Mgi Jnum | J:358046 | Mgi Id | MGI:7779629 |
| Citation | Pregizer S, et al. (2018) A Novel Mouse Model to Elucidate the Role of Gdf5 in Postnatal Joints. Orthopedic Research Society Annual Meeting :Abstract 0007 |
| abstractText | Growth and Differentiation Factor 5 (Gdf5), a member of the BMP superfamily, is expressed in all joints during the earliest stages of development and mutations in Gdf5 underlie brachydactylies in humans and brachypodism in mice, pointing to the importance of Gdf5 in joint morphogenesis. Additionally, genetic association studies have identified a strong link between Gdf5 and osteoarthritis (OA). People with variant Gdf5 sequences that predict reduced Gdf5 expression are more likely to develop knee and hip OA in adult life, suggesting that Gdf5 has a fundamental role in joint health. Due to the limitations of current mouse models, it remains unclear if the influence of Gdf5 in OA is due to late manifestations of altered joint development or to a specific role for Gdf5 in the maturation and/or subsequent maintenance of joints in postnatal life. Studies addressing this fundamental question require mice harboring a conditional Gdf5 allele that can be inactivated after joint development is complete. Here, we describe the development of a novel mouse model that allows us both to monitor Gdf5 expression and to inactivate Gdf5 in postnatal joints. |
