Primary Identifier | MGI:3665173 | Allele Type | Targeted |
Attribute String | Hypomorph, Inserted expressed sequence, Modified isoform(s) | Gene | Brca1 |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A gene fragment including part of exon 11 and all of intron 11 and exon 12 was replaced with a cDNA that results in joining of exon 11 to all exons 3' of exon 11. RT-PCR and Northern blot analysis confirmed the absence of transcript of the alternative splicing form of Brca1 that lacks exon 11; however, full length transcript is present. |