| Primary Identifier | MGI:1922589 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 75339 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable chromatin binding activity; histone reader activity; and methylated histone binding activity. Predicted to be involved in negative regulation of gene expression via chromosomal CpG island methylation; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and positive regulation of DNA methylation-dependent heterochromatin formation. Predicted to be located in cytosol; nuclear lumen; and plasma membrane. Predicted to be part of heterochromatin and nucleosome. Predicted to be active in cytoplasm and nucleus. Is expressed in inner cell mass and trophectoderm. Orthologous to human MPHOSPH8 (M-phase phosphoprotein 8). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality prior to E11.5. Mice homozygous for a null allele activated in neurons exhibit increased brain size, altered brain architecture, and behavioral changes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
