| First Author | van Oers NS | Year | 1996 |
| Journal | Immunity | Volume | 5 |
| Issue | 5 | Pages | 429-36 |
| PubMed ID | 8934570 | Mgi Jnum | J:37940 |
| Mgi Id | MGI:85334 | Doi | 10.1016/s1074-7613(00)80499-9 |
| Citation | van Oers NS, et al. (1996) alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity 5(5):429-36 |
| abstractText | Two families of protein tyrosine kinases (PTKs), the Src and Syk/ZAP-70 families, are required for T cell development. Lck is the major Src family member required for thymopoiesis, since there is a severe deficit of CD4+CD8+ thymocytes and mature T cells in its absence. However, some peripheral T cells are evident in these mice, suggesting that additional PTKs may contribute to T cell development. Here we show that the combined disruption of Lck and Fyn (lck(-/-)fyn(-/-)) completely arrests alpha beta T cell development at the CD4-CD8- stage. The development of V gamma 3+ dendritic epidermal T cells is also severely impaired, but natural killer cell development and cytolytic activity is unaffected in lck(-/-)fyn(-/-) mice. These findings reveal the potential for redundant functions mediated by Src family PTKs while emphasizing crucial roles for Lck and Fyn in T cell development. |
