| First Author | Fyhrquist N | Year | 2012 |
| Journal | J Invest Dermatol | Volume | 132 |
| Issue | 6 | Pages | 1672-80 |
| PubMed ID | 22402436 | Mgi Jnum | J:188756 |
| Mgi Id | MGI:5441696 | Doi | 10.1038/jid.2012.40 |
| Citation | Fyhrquist N, et al. (2012) Foxp3+ cells control Th2 responses in a murine model of atopic dermatitis. J Invest Dermatol 132(6):1672-80 |
| abstractText | The role of Foxp3+ regulatory T (Treg) cells in atopic dermatitis (AD) is still unclear. In a murine AD model, the number of Foxp3+ cells increased in the allergen-exposed skin area and in the secondary lymphoid organs. Both Foxp3+ and Foxp3- IL-10+ T cells accumulated at the site of allergen exposure, and CD103+ effector/memory Foxp3+ Treg cells expanded gradually in the lymph nodes throughout the sensitization protocol. The depletion of Foxp3+ Treg cells led to significantly exacerbated skin inflammation, including increased recruitment of inflammatory cells and expression of T helper type 2 cytokines, as well as elevated serum IgE levels. The effect of depleting Treg cells during epicutaneous sensitization was mirrored off by a stronger inflammatory response also in the lungs following airway challenge. Thus, Treg cells have an important role in controlling AD-like inflammation and the transfer of allergic skin inflammation to the lungs. |
