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Protein Coding Gene : Faah fatty acid amide hydrolase
Primary Identifier  MGI:109609 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  14073
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables acylglycerol lipase activity. Involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Is active in glutamatergic synapse. Is expressed in several structures, including brain; ganglia; gut; olfactory epithelium; and renal calyx. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase).
PHENOTYPE: Homozygotes for a null allele show high brain anandamide (AEA) levels, reduced pain sensation, altered behavioral responses to AEA, and sex-specific changes in ethanol intake and sensitivity. Homozygotes for the C385A variant show enhanced cued fear extinction and reduced anxiety-like behavior. [provided by MGI curators]
  • synonyms:
  • AW412498,
  • fatty acid amide hydrolase,
  • MGI:2140571,
  • MGD-MRK-39608,
  • expressed sequence AW412498,
  • Faah
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Features --> Cross References

Genome

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4 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

4 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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