| First Author | Duchez AC | Year | 2019 |
| Journal | Prostaglandins Other Lipid Mediat | Volume | 143 |
| Pages | 106340 | PubMed ID | 31129176 |
| Mgi Jnum | J:289292 | Mgi Id | MGI:6434960 |
| Doi | 10.1016/j.prostaglandins.2019.106340 | Citation | Duchez AC, et al. (2019) Respective contribution of cytosolic phospholipase A2alpha and secreted phospholipase A2 IIA to inflammation and eicosanoid production in arthritis. Prostaglandins Other Lipid Mediat 143:106340 |
| abstractText | Phospholipase A2s (PLA2) play a key role in generation of eicosanoids. Cytosolic PLA2alpha (cPLA2alpha) is constitutively expressed in most cells, whereas IIA secreted PLA2 (sPLA2-IIA) is induced during inflammation and is present at high levels in the synovial fluid of rheumatoid arthritis patients. In mice, both cPLA2alpha and sPLA2-IIA have been implicated in autoimmune arthritis; however, the respective contribution of these two enzymes to the pathogenesis and production of eicosanoids is unknown. We evaluated the respective role of cPLA2alpha and sPLA2-IIA with regard to arthritis and eicosanoid profile in an in vivo model of arthritis. While arthritis was most severe in mice expressing both enzymes, it was abolished when both cPLA2alpha and sPLA2-IIA were lacking. cPLA2alpha played a dominant role in the severity of arthritis, although sPLA2-IIA sufficed to significantly contribute to the disease. Several eicosanoids were modulated during the course of arthritis and numerous species involved sPLA2-IIA expression. This study confirms the critical role of PLA2s in arthritis and unveils the distinct contribution of cPLA2alpha and sPLA2-IIA to the eicosanoid profile in arthritis. |
