| First Author | Attaai A | Year | 2018 |
| Journal | Glia | Volume | 66 |
| Issue | 8 | Pages | 1695-1708 |
| PubMed ID | 29575117 | Mgi Jnum | J:273117 |
| Mgi Id | MGI:6285335 | Doi | 10.1002/glia.23332 |
| Citation | Attaai A, et al. (2018) Postnatal maturation of microglia is associated with alternative activation and activated TGFbeta signaling. Glia 66(8):1695-1708 |
| abstractText | Microglia are involved in a widespread set of physiological and pathological processes and further play important roles during neurodevelopmental events. Postnatal maturation of microglia has been associated with the establishment of microglia-specific gene expression patterns. The mechanisms governing microglia maturation are only partially understood but Tgfbeta1 has been suggested to be one important mediator. In the present study, we demonstrate that early postnatal microglia maturation is associated with alternative microglia activation, increased engulfment of apoptotic cells as well as activated microglial Tgfbeta signaling. Interestingly, microglial Tgfbeta signaling preceded the induction of the microglia-specific gene expression indicating the importance of Tgfbeta1 for postnatal microglia maturation. Moreover, we provide evidence that Tgfbeta1 is expressed by neurons in postnatal and adult brains defining neuron-microglia communication via Tgfbeta1 as an important event. Finally, we introduce the recently identified microglia marker Tmem119 as a direct Tgfbeta1-Smad2 target gene. Taken together, the data presented here further increase the understanding of Tgfbeta1-mediated effects in microglia and place emphasis on the importance of Tgfbeta1 for microglia maturation and maintenance. |
