Primary Identifier | MGI:1889505 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 53625 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Predicted to enable N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; protein glycosylation; and sensory perception of smell. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and nose. Orthologous to human B3GNT2 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2). PHENOTYPE: Homozygotes for a gene trap allele show severe axon guidance errors and specific loss of olfactory sensory neurons and glomeruli. Homozygotes for another gene trap allele show hyperactive lymphocytes and macrophages. Homozygotes for a reporter allele display behavioral despair and reduced anxiety. [provided by MGI curators] |