| First Author | Church C | Year | 2010 |
| Journal | Nat Genet | Volume | 42 |
| Issue | 12 | Pages | 1086-92 |
| PubMed ID | 21076408 | Mgi Jnum | J:166829 |
| Mgi Id | MGI:4849865 | Doi | 10.1038/ng.713 |
| Citation | Church C, et al. (2010) Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet 42(12):1086-92 |
| abstractText | Genome-wide association studies have identified SNPs within FTO, the human fat mass and obesity-associated gene, that are strongly associated with obesity. Individuals homozygous for the at-risk rs9939609 A allele weigh, on average, ~3 kg more than individuals with the low-risk T allele. Mice that lack FTO function and/or Fto expression display increased energy expenditure and a lean phenotype. We show here that ubiquitous overexpression of Fto leads to a dose-dependent increase in body and fat mass, irrespective of whether mice are fed a standard or a high-fat diet. Our results suggest that increased body mass results primarily from increased food intake. Mice with increased Fto expression on a high-fat diet develop glucose intolerance. This study provides the first direct evidence that increased Fto expression causes obesity in mice. |
