| Primary Identifier | MGI:3711057 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(HLA-A/H2-D/B2M)1Dvs |
| Strain of Origin | NOD/ShiLtDvs | Is Recombinase | false |
| Is Wild Type | false |
| description | The HDD construct was created and used to generate a differnet transgenic mouse line in J:41077. |
| molecularNote | This transgene encodes a human B2-microglubulin (B2M) covalently linked to the MHC class 1, alpha1 and alpha2 binding domains of the human HLA-A2.1 gene, and the alpha3, cytoplasmic and transmembrane domains of the murine H2-Db. The construct was injected into fertilized NOD/ShiLtDvs oocytes. The construct was originally described in J:41077 and used to create a different transgenic line. |
