| First Author | Ayhan Y | Year | 2009 |
| Journal | Behav Brain Res | Volume | 204 |
| Issue | 2 | Pages | 274-81 |
| PubMed ID | 19379776 | Mgi Jnum | J:152112 |
| Mgi Id | MGI:4356235 | Doi | 10.1016/j.bbr.2009.04.010 |
| Citation | Ayhan Y, et al. (2009) Animal models of gene-environment interactions in schizophrenia. Behav Brain Res 204(2):274-81 |
| abstractText | The pathogenesis of schizophrenia and related mental illnesses likely involves multiple interactions between susceptibility genes of small effects and environmental factors. Gene-environment interactions occur across different stages of neurodevelopment to produce heterogeneous clinical and pathological manifestations of the disease. The main obstacle for mechanistic studies of gene-environment interplay has been the paucity of appropriate experimental systems for elucidating the molecular pathways that mediate gene-environment interactions relevant to schizophrenia. Recent advances in psychiatric genetics and a plethora of experimental data from animal studies allow us to suggest a new approach to gene-environment interactions in schizophrenia. We propose that animal models based on identified genetic mutations and measurable environment factors will help advance studies of the molecular mechanisms of gene-environment interplay. |
