| First Author | Surman DR | Year | 2000 |
| Journal | J Immunol | Volume | 164 |
| Issue | 2 | Pages | 562-5 |
| PubMed ID | 10623795 | Mgi Jnum | J:140160 |
| Mgi Id | MGI:3812190 | Doi | 10.4049/jimmunol.164.2.562 |
| Citation | Surman DR, et al. (2000) Cutting edge: CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen. J Immunol 164(2):562-5 |
| abstractText | Neoantigens resulting from the inherent genomic instability of tumor cells generally do not trigger immune recognition. Similarly, transfection of tumors with model Ags often fails to elicit CD8+ T cell responses or alter a tumor's growth rate or lethality. We report here that the adoptive transfer of activated Th1-type CD4+ T cells specific for a model tumor Ag results in the de novo generation of CD8+ T cells with specificity to that Ag and concomitant tumor destruction. The anti-tumor effects of the CD4+ T cells required the presence of both MHC class I and class II on host cells, as evidenced by experiments in knockout mice, suggesting that CD4+ T cells enhanced the ability of host APC to activate endogenous CD8+ T cells. These results indicate that the apparent inability of tumor cells expressing highly immunogenic epitopes to activate tumor-specific CD8+ T cells can be altered by activated CD4+ T cells. |
