Primary Identifier | MGI:894835 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 19647 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein kinase binding activity and ubiquitin protein ligase activity. Involved in ubiquitin-dependent protein catabolic process. Acts upstream of or within embryonic organ development; in utero embryonic development; and somite development. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with centrosome. Is expressed in lung; tongue; and upper jaw. Orthologous to human RBBP6 (RB binding protein 6, ubiquitin ligase). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality, reduced size, growth retardation and increased apoptosis. [provided by MGI curators] |