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Protein Coding Gene : Rbbp6 retinoblastoma binding protein 6, ubiquitin ligase

Primary Identifier  MGI:894835 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  19647
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable protein kinase binding activity and ubiquitin protein ligase activity. Involved in ubiquitin-dependent protein catabolic process. Acts upstream of or within embryonic organ development; in utero embryonic development; and somite development. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with centrosome. Is expressed in lung; tongue; and upper jaw. Orthologous to human RBBP6 (RB binding protein 6, ubiquitin ligase).
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality, reduced size, growth retardation and increased apoptosis. [provided by MGI curators]
  • synonyms:
  • AI316869,
  • RIKEN cDNA 4933422O15 gene,
  • MGI:1924749,
  • BB233631,
  • retinoblastoma binding protein 6, ubiquitin ligase,
  • expressed sequence BB233631,
  • MGI:1344330,
  • MGI:1921709,
  • C030034J04Rik,
  • C77662,
  • Rbbp6,
  • RIKEN cDNA C030034J04 gene,
  • expressed sequence C77662,
  • MGI:2142318,
  • expressed sequence AI316869,
  • 4933422O15Rik,
  • MGI:2142301,
  • MGI:2141903

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