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GO Term : ATAC complex [GO:0140672] Gene Ontology
Namespace  cellular_component Obsolete  false
description  A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation.
  • synonyms:
  • Ada Two-A containing complex,
  • KAT2B-containing ATAC complex,
  • Ada-Two-A-containing complex,
  • Ada two A containing complex,
  • ADA2A-containing complex,
  • KAT2A-containing ATAC complex,
  • G-ATAC complex
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