| First Author | Llorens-Bobadilla E | Year | 2023 |
| Journal | Nat Biotechnol | PubMed ID | 36604544 |
| Mgi Jnum | J:356170 | Mgi Id | MGI:7762262 |
| Doi | 10.1038/s41587-022-01603-9 | Citation | Llorens-Bobadilla E, et al. (2023) Solid-phase capture and profiling of open chromatin by spatial ATAC. Nat Biotechnol 41(8):1085-1088 |
| abstractText | Current methods for epigenomic profiling are limited in their ability to obtain genome-wide information with spatial resolution. We introduce spatial ATAC, a method that integrates transposase-accessible chromatin profiling in tissue sections with barcoded solid-phase capture to perform spatially resolved epigenomics. We show that spatial ATAC enables the discovery of the regulatory programs underlying spatial gene expression during mouse organogenesis, lineage differentiation and in human pathology. |
