| First Author | Essien FB | Year | 1981 |
| Journal | Teratology | Volume | 24 |
| Issue | 2 | Pages | 235-9 |
| PubMed ID | 7336364 | Mgi Jnum | J:6726 |
| Mgi Id | MGI:55199 | Doi | 10.1002/tera.1420240214 |
| Citation | Essien FB, et al. (1981) A genetic factor controlling morphogenesis of the laryngotracheo-esophageal complex the mouse. Teratology 24(2):235-9 |
| abstractText | A new autosomal, recessive lethal mutation in the mouse cause failure of division of the embryonic foregut into totally separate digestive and respiratory ducts. The newborn homozygote has a cleft that extends between the laryngotracheal and esophageal tubes, allowing excessive air to pass into the stomach and subsequently into the peritoneal cavity. This mutation has been designated lec (laryngotracheo-esophageal cleft). The common region shared by the respiratory and digestive tubes has features characteristic of both structures. Development of cartilage around the laryngotracheo-esophageal complex is also affected in the mutant. |
