| First Author | Rogalla MM | Year | 2020 |
| Journal | eNeuro | Volume | 7 |
| Issue | 3 | PubMed ID | 32327469 |
| Mgi Jnum | J:289182 | Mgi Id | MGI:6431160 |
| Doi | 10.1523/ENEURO.0511-19.2020 | Citation | Rogalla MM, et al. (2020) Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice. eNeuro 7(3):ENEURO.0511-19.2020 |
| abstractText | Alterations in inhibitory circuits of the primary auditory cortex (pAC) have been shown to be an aspect of aging and age-related hearing loss (AHL). Several studies reported a decline in parvalbumin (PV) immunoreactivity in aged rodent pAC of animals displaying AHL and conclude a relationship between reduced sensitivity and declined PV immunoreactivity. However, it remains elusive whether AHL or a general molecular aging is causative for decreased PV immunoreactivity. In this study, we aimed to disentangle the effects of AHL and general aging on PV immunoreactivity patterns in inhibitory interneurons of mouse pAC. We compared young and old animals of a mouse line with AHL (C57BL/6) and a mutant (C57B6.CAST-Cdh23(Ahl+) ) that is not vulnerable to AHL according to their hearing status by measuring auditory brainstem responses (ABRs) and by an immunohistochemical evaluation of the PV immunoreactivity patterns in two dimensions (rostro-caudal and layer) in the pAC. Although AHL could be confirmed by ABR measurements for the C57BL/6 mice, both aged strains showed a similar reduction of PV(+) positive interneurons in both, number and density. The pattern of reduction across the rostro-caudal axis and across cortical layers was similar for both aged lines. Our results demonstrate that a reduced PV immunoreactivity is a sign of general, molecular aging and not related to AHL. |
