| First Author | Yao Y | Year | 2018 |
| Journal | RNA Biol | Volume | 15 |
| Issue | 12 | Pages | 1477-1486 |
| PubMed ID | 30474472 | Mgi Jnum | J:324591 |
| Mgi Id | MGI:6850883 | Doi | 10.1080/15476286.2018.1551705 |
| Citation | Yao Y, et al. (2018) Long noncoding RNA Malat1 is not essential for T cell development and response to LCMV infection. RNA Biol 15(12):1477-1486 |
| abstractText | Long noncoding RNAs (lncRNAs) are emerging as critical mediators of various biological processes in the immune system. The current data showed that the lncRNA Malat1 is highly expressed in T cell subsets, but the function of Malat1 in T cell remains unclear. In this study, we detected the T cell development and both CD8(+) and CD4(+) T cell response to LCMV infection using Malat1(-/-) mice model. To our surprise, there were no significant defects in thymocytes at different developmental stages and the peripheral T cell pool with ablation of Malat1. During LCMV infection, Malat1(-/-) mice exhibited normal effector and memory CD8(+) T cells as well as TFH cells differentiation. Our results indicated that Malat1 is not essential for T cell development and T cell-mediated antiviral response though it expresses at very high level in different T cell populations. |
