Primary Identifier | MGI:2179707 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Nfkb1 |
Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A neomycin resistance cassette was inserted into the gene, disrupting the carboxy terminal domain of the encoded protein. Western blot analysis on lystates derived from thymus of homozygous mice confirmed that the p50 isoform of the protein was expressed, but the p105 precursor was not detectable. |