Primary Identifier | MGI:108466 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 19765 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including doxorubicin transport; positive regulation of mitochondrial fission; and xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in mitochondrion; nuclear body; and plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse and membrane. Used to study microphthalmia. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). PHENOTYPE: Homozygous and heterozygous null mice display increased sensitivity to X-ray irradiation, increased oxidative stress, and impaired glutathione homeostasis. Mice homozygous for a gene trap insertion exhibit decreases in exploratory and locomotor activity and a decreased sensitivity to pain. [provided by MGI curators] |