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Publication : Sox9 induces testis development in XX transgenic mice.

First Author  Vidal VP Year  2001
Journal  Nat Genet Volume  28
Issue  3 Pages  216-7
PubMed ID  11431689 Mgi Jnum  J:76138
Mgi Id  MGI:2178704 Doi  10.1038/90046
Citation  Vidal VP, et al. (2001) Sox9 induces testis development in XX transgenic mice. Nat Genet 28(3):216-7
abstractText  Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.
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