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Allele : Or8a1<tm39(Gnas*)Mom> olfactory receptor family 8 subfamily A member 1; targeted mutation 39, Peter Mombearts
Primary Identifier  MGI:5784884 Allele Type  Targeted
Attribute String  Constitutively active, Hypomorph, Inserted expressed sequence Gene  Or8a1
Inheritance Mode  Not Specified Transmission  Germline
Strain of Origin  129P2/OlaHsd Is Recombinase  false
Is Wild Type  false
molecularNote  Two amino acid substitutions (D121R;R122D) were made to change the highly conserved DRY motif to RDY to diminish G-protein signalling, and an internal ribosome entry site followed by a constitutively active Gnas coding sequence (due to a Q227L sequence change) was inserted just downstream of the endogenous coding sequence to give bicistronic expression.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • M71(RDY)-caGs-GFP,
  • M71(RDY)-caGs-GFP
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

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0 Driven By

4 Publication categories

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