| First Author | Sidwell RW | Year | 1995 |
| Journal | J Infect Dis | Volume | 171 Suppl 2 |
| Pages | S93-8 | PubMed ID | 7861024 |
| Mgi Jnum | J:23290 | Mgi Id | MGI:71055 |
| Doi | 10.1093/infdis/171.supplement_2.s93 | Citation | Sidwell RW, et al. (1995) Effect of the combination of interferon-alpha and stavudine on Friend virus infections in (B10.A x A.By)F1 mice. J Infect Dis 171 Suppl 2:S93-8 |
| abstractText | The anti-Friend leukemia virus (FLV) effects of interferon-alpha-A/D (IFN-alpha) and 2',3'-didehydro-2',3'-dideoxythymidine (stavudine) used alone and in combination were examined in Mus dunni cells using a checkerboard-type experiment design. Strong antiviral synergy and a suggested cytotoxic synergy were seen. In two experiments to evaluate the effect of combining therapy with IFN-alpha and stavudine against FLV disease in the hybrid mouse strain (B10.A x A.By)F1, which is a strong producer of cytotoxic T cells, the drug combination resulted in better inhibition of FLV disease than did either drug used alone. Combination therapy inhibited splenomegaly, splenic virus infectious centers, plasma virus, and the virus-induced increase in hematocrit to a greater degree than did either drug alone. These data indicate that combination therapy with stavudine and IFN-alpha is effective in the treatment of murine retrovirus infections and may be of value in the treatment of human AIDS. |
