| Primary Identifier | MGI:5645358 | Allele Type | Targeted |
| Attribute String | Conditional ready | Gene | Nras |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The 5' untranslated region (5'-UTR) of the gene is interrupted 1,046 base pairs downstream of the transcription start site by a splice acceptor followed by a 3XSTOP transcriptional/translational termination sequence and a single frt site (remaining after excision of a selection cassette from Nrastm1Nesh by FLP recombinase). A single point mutation in exon 2 has replaced a nucleotide triplet encoding glutamine at amino acid position 61 with an arginine codon (Q61R); this represents the predominant NRAS mutation observed in human melanomas. |
