| Primary Identifier | IPR045577 | Type | Domain |
| Short Name | SENP3_5_cons_dom |
| description | Sentrin/SUMO-specific proteases (SENPs) reversibly regulate the covalent modification of proteins by SUMO. SENP3 and 5 share considerable sequence homology and exhibit similar substrate specificity,as they are active against SUMO-2 and SUMO-3 but less so for SUMO-1. They are more closely related than to SENP1/2. This entry covers the N-terminal region of SENP3/5 containing a conserved domain directly preceding the catalytic domain. This domain is responsible for the subcellular localisation []. SENP3/5 co-localise in the nucleolus and their depletion causes defects in ribosome biogenesis []. |
