| First Author | Danielson LS | Year | 2015 |
| Journal | Leuk Res | Volume | 39 |
| Issue | 3 | Pages | 335-41 |
| PubMed ID | 25597017 | Mgi Jnum | J:232684 |
| Mgi Id | MGI:5779792 | Doi | 10.1016/j.leukres.2014.12.002 |
| Citation | Danielson LS, et al. (2015) Limited miR-17-92 overexpression drives hematologic malignancies. Leuk Res 39(3):335-41 |
| abstractText | The overexpression of microRNA cluster miR-17-92 has been implicated in development of solid tumors and hematological malignancies. The role of miR-17-92 in lymphomagenesis has been extensively investigated; however, because of the developmental defects caused by miR-17-92 dysregulation, its ability to drive tumorigenesis has remained undetermined until recently. Here we demonstrate that overexpression of miR-17-92 in a limited number of hematopoietic cells is sufficient to cause B cell malignancies. In sum, our study provides a novel and physiologically relevant model that exposes the potent ability of miR-17-92 to act as a driver of tumorigenesis. |
