| Primary Identifier | IPR007884 | Type | Family |
| Short Name | METL9 |
| description | This family contains protein-histidine N-methyltransferases (also known as DORA reverse strand protein DREV) that specifically catalyse 1-methylhistidine (pros-methylhistidine) methylation of target proteins, such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12 [, ]. They mediate methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid), in which the 1-methylhistidine modification may affect the binding of zinc and other metals []. These proteins constitute the main methyltransferase for the 1-methylhistidine modification in cell []. |
